![]() Martono, Doti P Hak, Eelko Lambers Heerspink, Hiddo Wilffert, Bob Denig, Petra Predictors of HbA 1 c levels in patients initiating metformin. Thus, excess body weight may be the primary therapeutic target to prevent the early onset of diabetes, regardless of the individual's HbA 1 c. Our results suggest that approximately half of the obese individuals with HbA 1 c in the normal range develop prediabetes or diabetes within 8 years, whereas low-body-weight individuals with high-normal HbA 1 c are less likely to exhibit worsening in glycemia. Similar changes occurred in the other groups during the study, resulting in a linear increase in HbA 1 c levels with increasing BMI. In contrast, in 77 low-body-weight subjects with a high-normal baseline HbA 1 c (BMI ≤ 18.9 kg/m(2), HbA 1 c 5.7-6.4%), the mean HbA 1 c level remained constant. In 405 obese subjects with a normal baseline HbA 1 c (BMI ≥ 27.0 kg/m(2), HbA 1 c 5.2-5.6%), the mean HbA 1 c level increased during the study period, and 50.9% developed prediabetes/diabetes. ![]() The subjects were then classified into six baseline BMI categories, each of which was divided into two HbA 1 c groups, resulting in a total of 12 groups. We analyzed clinical parameters, including body mass index (BMI) and HbA 1 c levels, in 5325 non-diabetic Japanese people aged 20-75 years who underwent four medical checkups between 1999 (baseline) and 2007. Therefore, we addressed this issue in a longitudinal study. ![]() Obese individuals with normal HbA 1 c levels and low-body-weight individuals with high-normal HbA 1 c levels are frequently encountered in clinical settings, but the effects of these phenotypes on the onset of diabetes are poorly understood. Excess body weight affects HbA 1 c progression irrespective of baseline HbA 1 c levels in Japanese individuals: a longitudinal retrospective study.
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